Autoradiographic analysis of lymphocyte proliferation in the thymus and in thymic lymphoma tissue.

Autoradiographic Analysis of Lymphopoiesis and Lymphocyte Migration in Mice Bearing Multiple Thymus Grafts

Lymphopoiesis was studied in 3-month-old normal C57Bl mice and in 3-month-old C57Bl mice carrying from 12 to 48 C57Bl thymus grafts using tritiated thymidine labeling. Thymus graft lymphopoiesis was found to be identical with that of normal thymus tissue and the presence of thymus grafts was found to have no influence on host thymus lymphopoiesis. No evidence was found that the massive amounts ...

Wnt4 signaling is associated with the decrease of proliferation and increase of apoptosis during age-related thymic involution.

The thymus is a central lymphoid organ that is responsible for T-lymphocyte development and maturation. Through negative and positive selection, lymphoid progenitor cells, which initiate from the bone marrow, develop into mature T cells in the thymus, and are subsequently involved in peripheral cell immunity. It has been reported that the Wnt signaling pathway exists widely in thymic epithelial...

Thymic lymphopoiesis and cell loss in newborn mice.

By W. D. Mica uio,, M. W. HESS, H. RIEDWYL, R. D. STONER AND H. COrnER T HE ROLE of the thymus as one of a controlling organ in the development of immunity has been advocated in recent years based on both clinical”2 and experimental observations.”4 The mechanism ( s ) whereby the thymus might directly or indirectly exert its influence on the lymphoreticular tissue throughout the body are not cl...

Differentiation and maturation of functional T lymphocyte subsets in the thymus. I. Effect of irradiation of the thymus.

Nature of the Stimulating Cell in the Syngeneic and the Allogeneic Mixed Lymphocyte Reaction in Mice

Thymus cells from CBA and BALB/c mice are stimulated by syngeneic peripheral lymphoid cells in a "one-way" mixed lymphocyte reaction. The stimulating cell appears to be a mature B cell. Spleen cells from neonatal mice and thymus cells or bone marrow cells from adult mice are not able to induce DNA synthesis in syngeneic thymus cells, although they stimulate significantly allogeneic thymocytes. ...